The compounds with biological activity cannot be tested directly in humans, which makes it important to build disease models that truthfully reflect the pathology of diseases, which can effectively and economically help to explore the activity and corresponding mechanism of the compounds. The screening model is a pharmacological experimental model used in drug screening experiments. Drug screening can be divided into biochemical and cellular screening, or phenotypic and target-based screening. The contributions of both phenotypic and target-based methodologies will be important in discovering new medicines and they should be seen as complementing rather than competing against each other.
Target-based screening experiments are designed by using the target of the drug to be developed, which is usually a protein with specific physiological functions. The basis for screening the compound is the effect of the compound on the target which can be quantitatively determined by methods such as fluorescence, light absorption, chemiluminescence, enzyme-linked immunity, nuclear magnetic resonance etc.
Fig 1 The flow chart of target-based drug discovery.
ALL Chemistry’s targets cover various enzymes, GPCRs, ion channels, nuclear receptors, PDE, and more. And all assays are completely customizable to suit your demands.
* Enzyme-based Screening
* Ion Channel-based Screening
* GPCR-based Screening
* Nuclear Receptor-based Screening
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