Custom Nucleic Acids


Nucleic acids are biopolymers that play a vital role in the storage, expression, and transmission of genetic information in all living organisms. There are two main types of nucleic acids: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).

DNA is a double-stranded molecule that contains the genetic information of an organism. It consists of four nucleotides: adenine (A), guanine (G), cytosine (C), and thymine (T). The sequence of these nucleotides determines the genetic code, which is the blueprint for the production of proteins in the cell.

RNA is a single-stranded molecule that plays a key role in the synthesis of proteins. It is made up of four nucleotides: A, G, C, and uracil (U). There are three main types of RNA: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). mRNA carries the genetic code from DNA to the ribosome, where it is translated into proteins. tRNA delivers amino acids to the ribosome, where they are assembled into proteins. rRNA forms the structure of the ribosome and catalyzes the formation of peptide bonds between amino acids.

Both DNA and RNA are made up of nucleotides, which consist of a sugar molecule, a phosphate group, and a nitrogenous base. The sugar molecule in DNA is deoxyribose, while the sugar molecule in RNA is ribose. The nitrogenous bases in DNA are A, G, C, and T, while the nitrogenous bases in RNA are A, G, C, and U.

Nucleic acids are fundamental to life, and they play a crucial role in the storage and transmission of genetic information from one generation to the next. They also have important applications in biotechnology, including the development of gene therapies, genetic engineering, and DNA sequencing.

ALL Chemistry Inc. provides custom nucleic acids which are synthetic or modified nucleic acids that are designed for specific research or therapeutic purposes. Custom nucleic acids can be made with modifications to their structure or sequence, allowing for a wide range of applications in molecular biology, genetics, and medicine. Custom nucleic acids have a wide range of applications, including gene expression analysis, gene editing, RNA interference, and antisense therapy. They are often used in research to study the function of specific genes or to develop new therapeutic strategies for genetic diseases.


Some of our common modifications to custom nucleic acids include:


Phosphorothioate linkages: Replacing the phosphate group in the backbone of DNA or RNA with a phosphorothioate group. This modification can enhance the stability and nuclease resistance of the nucleic acid.

Locked nucleic acids (LNAs): These are modified nucleotides that contain a methylene bridge connecting the 2' oxygen and 4' carbon atoms. This modification increases the stability of the nucleic acid and can improve its binding affinity.

2'-O-methyl RNA: This modification involves adding a methyl group to the 2' oxygen atom of the ribose sugar in RNA. This modification can enhance the stability and nuclease resistance of RNA.

Fluorescent dyes: Custom nucleic acids can be labeled with fluorescent dyes to enable visualization and tracking in experiments.

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