The Introduction of Chalcones:

Chalcones are a group of plant-derived polyphenolic compounds that possess a wide variety of biological activities. Chalcones are known for their diverse biological activities and medicinal properties. Chalcones are active lead molecules in medicinal chemistry for the discovery of new drugs. The chalcone core is composed of two aromatic rings that are linked through a three-carbon, -unsaturated carbonyl system, i.e., 1,3-diphenyl-2-propen-1-one derivative. Chalcones are structurally one of the most diverse groups of flavonoids and easily allow for cyclization, forming flavonoid structures. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potential against various diseases.

Several lead compounds with various pharmacological properties have been developed based on the chalcone skeleton. The beneficial effect of these substances has been studied in relation to diabetes mellitus. The unique structure of chalcones gives chalcones their characteristic yellow color and imparts them with a wide range of biological activities, including antioxidant, anti-inflammatory, anticancer, antimicrobial, and antiviral properties. Due to their potential therapeutic applications, chalcones have attracted considerable attention from researchers in the fields of pharmacy, medicine, and natural product chemistry.



Fig 1 Core Structure of Chalcone Molecule

Pharmacological Activity of Chalcones:


Chalcone and Its Derivatives have Diverse Pharmacological Activities.

--Anti-Bacterial Agent: Chalcone is an antibacterial agent with moderate to high activity due to the presence of the reactive αβ-unsaturated system. Their flexibility to change their structure by incorporating different types of substituent groups into the aromatic ring can potentially achieve a higher potency, lower toxicity, and a wider spectrum of antibacterial activity 

--Anti-inflammatory agent: Chalcones have been found to inhibit the production of pro-inflammatory cytokines and enzymes, thus reducing inflammation in various tissues and organs. This anti-inflammatory activity makes chalcones potential candidates for the treatment of inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma.

--Anti-Fungal Agent: Chalcones act on glutathione, cysteine molecules, and proteins involved in the cell separation of yeast cells. A hybrid molecule of the pharmacophore fluconazole and chalcone was tested for its antifungal activity and showed inhibitory activity against Candida albicans. Chalcone with an unsubstituted thiophene ring B and thiomethyl substitution at the p-position of ring A (compared to o- and m-) produced credible antifungal activity on fluconazole-sensitive and fluconazole-resistant strains of yeast.

--Anti-Malarial Agent: Chalcones have shown promising potential as antimalarial agents in the fight against malaria. These natural compounds, found in various plants, possess unique chemical structures that allow for modifications to enhance their pharmacological properties. Studies have demonstrated that chalcones can inhibit key enzymes involved in the survival and replication of the malaria parasite, such as dihydrofolate reductase (DHFR). Additionally, chalcones have exhibited potent antimalarial activity against both drug-sensitive and drug-resistant strains of Plasmodium. Further research and development in this field may lead to the discovery of novel chalcone derivatives with improved efficacy and reduced toxicity, providing new options for the treatment and control of malaria.

--Anti-Cancer Agent: Chalcones have been shown to inhibit the growth and proliferation of cancer cells, induce apoptosis (programmed cell death), and suppress tumor angiogenesis. Furthermore, chalcones have been found to sensitize cancer cells to chemotherapy drugs, enhancing their effectiveness. These findings suggest that chalcones could be used as adjuvants in cancer treatment, potentially improving patient outcomes.

Chalcone compounds show great potential for the development of novel therapeutics in various disease areas. Future research and development in this field will undoubtedly uncover new insights into the therapeutic applications of chalcones and contribute to advancements in drug discovery and development.


Product Description:


Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, collectively known as chalcones. Chalcones are found as intermediates in the biosynthesis of flavonoids and isoflavanoids, which have a broad spectrum of biological functions in plants. Compounds with a chalcone backbone have anti-bacterial, anti-fungal, anti-viral, anti-tumor and anti-inflammatory properties. The chalcone compounds offered by ALL Chemistry have been extensively studied for their pharmacological properties. These compounds exhibit diverse activities, including antioxidant, anti-inflammatory, anticancer, antimicrobial, and antiviral effects.

At ALL Chemistry, we prioritize quality and customer satisfaction. Our chalcone compounds undergo rigorous quality control processes to ensure their purity, stability, and consistency. We offer a wide selection of chalcone derivatives, allowing researchers to choose the most suitable compounds for their specific needs. Whether you are conducting research in drug discovery, natural product chemistry, or organic synthesis, our chalcone compounds provide an invaluable resource for your scientific endeavors. Trust ALL Chemistry for reliable and high-quality chalcone compounds that meet your research requirements.


Partial Product Details:


Product Category

CAS Number

Product Name


Molecular Formula








Loureirin D















Pinocembrin chalcone





Flavokawain C
























Please contact us for further information if you have a purchase requirement, including pricing, samples, and technical specifications. We look forward to providing our chalcone products. In addition, ALL Chemistry provides a seamless one-stop process development service, ALL Chemistry can provide synthesis and fine chemicals services if the existing products can't meet your needs, we have expertise in the synthesis of a broad array of customized molecules, and we offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.

Product Advantage:


Provide quality-guaranteed products, all products are provided with a quality analysis report (COA), use advanced instruments such as MS(Mass Spectrometry), HPLC and NMR (Nuclear Magnetic Resonance) for quality inspection.

Professional and reliable packaging ensures the safety and stability of products from transportation, storage to use.

ALL Chemistry provides chalcone products with a purity greater than 95%.

Access our expertise and technical support from anywhere, 24 hours a day-kindly please contact us if you need it.

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