Labeled Peptides


The Introduction of Labeled Peptides:


Peptide is a compound formed by connecting amino acids with peptide bonds and is an intermediate product of protein hydrolysis. A compound formed by the dehydration and condensation of two amino acid molecules is called a dipeptide, and a peptide consisting of three or more amino acid molecules is called a polypeptide. Polypeptide generally refers to a class of compounds formed by dehydration and condensation of 3–50 -amino acids. According to different sources, it can be roughly divided into three categories: extracted p polypeptideschemical synthetic peptides, and gene-ecombinant p polypeptides. any peptides are synthesized in the nervous system, lymphoid tissue, and endocrine system. Peptides have strong biological activities and can regulate the functional activities of cells in living organisms. Polypeptide drugs have the advantages of strong patent medicine, high activity, good specificity, relatively weak toxic reactions, difficult accumulation, less drug cross-reaction, etc.

Stable isotope-labeled polypeptide refers to the polypeptide synthesized by amino acids labeled with stable isotopes. It's a technology that introduces isotopes with clear identification meaning on polypeptide substrates with clear functional meaning to make them unique in characterization to better realize quantitative analysis. Compared with standard amino acids, isotope-labeled peptides refer to peptides in which one or multiple atoms are substituted by isotope atoms (such as 2H, 13C, 18O, and 15N). It has unique nutritional properties and biological safety and can be used to track and locate the molecular activities of proteins and peptides, as well as to detect the interaction between different cells and tissues in organisms. The rescaled amino acids are non-radioactive, but their molecular weight is larger than the standard amino acids. This difference in molecular weight can make it a powerful tool in protein quantitative analysis, protein structure analysis, and MS (or NMR) identification. Isotope modification has attracted more and more attention in the medical and biochemical fields because of its high sensitivity, simple positioning, and accurate quantification.


Fig 1 Peptides

Uses of Labeled Peptides:


Isotope-labeled peptides have unique advantages and applications in the fields of metabolomics, food testing and quantitative proteomics, as follows:

-- In metabolomics: Metabolomics is the study of small molecules, known as metabolites, involved in cellular processes. Isotope-labeled polypeptides play a crucial role in metabolomics research. By using labeled peptides as internal standards, the position and quantity of isotope-labeled peptides can be tracked in vitro and in vivo to study the metabolic pathways of peptides.

-- In food testing: Isotope-labeled polypeptides are utilized for various purposes, including food authenticity, quality control, and traceability. These labeled peptides can be used as internal standards for the detection and quantification of contaminants, such as pesticides, toxins, or adulterants, in food samples. By incorporating stable isotopes into polypeptides, precise and accurate measurements can be made, ensuring the safety and compliance of food products. Labeled polypeptides also aid in the analysis of food composition, such as the determination of protein content or amino acid profiles, providing valuable information for nutritional labeling and quality assessment.

-- In quantitative proteomics: Polypeptides labeled with stable isotopes (13C, 15N, 13C15N) are widely used in the detection and tracing of biological samples as "chemical labels" in quantitative protein omics. The quantitative analysis method of protein omics mainly uses high-resolution mass spectrometry to separate isotope-labeled and unlabeled polypeptide ions or peptide segment ions, and uses the intensity value of its detection signal for quantitative calculation. By using labeled peptides as internal standards, researchers can precisely measure protein abundance, allowing for the identification of differently expressed proteins in various biological samples. This information aids in understanding disease mechanisms, identifying potential therapeutic targets, and evaluating drug responses.


Product Description:


Isotopes can be used to track the movement and change of substances. A method of studying organic reaction processes with the help of isotope atoms. That is, when isotopes are used to track the movement and change processes of substances, they are called tracer elements The chemical properties of compounds labeled with tracer elements remain unchanged.

ALL Chemistry is committed to providing customers with the most comprehensive variety of isotope-labeled peptides. To provide high-quality stable isotope-labeled peptides, ALL Chemistry has reached a strategic cooperation agreement with advanced isotope labeling manufacturers to ensure that we can provide a complete range of isotope-labeled peptide products with stable quality. Our custom peptides labeled with stable isotopes include 2H (deuterium), 15N, 13C.

Product Advantage:


ALL Chemistry is an integrated supply platform for stable isotopes, which can supply chemicals with stable isotopes such as deuterium D, carbon 13, oxygen 18 and nitrogen 15.

ALL Chemistry can provide some stable isotope-labeled peptides in stock, all products are provided with a quality analysis report (COA), and some products can provide NMR, MS, HPLC/GC spectra and detection methods.

ALL Chemistry provides isotope-labeled peptide products with the advantages of high sensitivity, simple location and accurate quantification.

ALL Chemistry provides isotope-labeled peptides with purity greater than 95%.

ALL Chemistry provides customized isotope-labeled peptide services to meet your requirements.

ALL Chemistry offers technical assistance and guidance in selecting the appropriate isotope-labeled peptides for your research.

Product details

ALL Chemistry can provide stable isotope-labeled peptides in stock, and some product information is as follows:


Fig 2 Aspartame-[d5]

Product Name: Aspartame-[d5]

Chemical Formula: C14H13D5N2O5

CAS Number: 1356849-17-6

Purity: ≥97%

Appearance: White to Off-white Solid

Solubility: Soluble in Aqueous Acid (Sparingly), DMSO (Slightly), Methanol (Slightly, Heated)

Description: Aspartame-[d5] is the labeled analog of Aspartame. Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages.


Please contact us for further information, including pricing, samples, and technical specifications. We look forward to providing our isotope-labeled peptide products. In addition, ALL Chemistry can provide synthesis and fine chemicals service if the existing products can't meet your needs, We have expertise in the synthesis of a broad array of customized molecules, and we offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.

Custom Chemical Synthesis is the process where a molecule is made exclusively for a particular client according to specifications at their scale. It is one of the options available for pharmaceutical companies requiring active pharmaceutical ingredients (APIs), intermediates, fine chemicals, reference standards, impurities or metabolites needed to launch their research and development projects. We provide a seamless one-stop process development service, effectively speeding up the process of new drug development and reducing overall costs. Available documents for custom synthesis projects: synthesis report, high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance analyses (NMR), etc.


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