Labeled Amino Acids


The Introduction of Labeled Amino Acids:

Amino acids are the building blocks of proteins and play a crucial role in various biological processes. Amino acids are organic compounds containing basic amino and acidic carboxyl groups formed by hydrogen atoms, in which amino groups replace carboxylic acids. Amino acids are important components of organisms, retain irreplaceable biological functions, and play a vital role in the metabolic circulation of organisms. Amino acids can be precursors to many other biomolecules (such as cytosine, adenine, adrenaline, etc.) and are essential building materials for proteins. At the same time, amino acids are widely used in medicine, food, cosmetics and other fields.

Labeled amino acids, also known as Isotope labeled amino acids, are amino acids that have been chemically modified by replacing one or more atoms with stable isotopes. Basically, Isotope labeled amino acids have the same structure and properties as non-labeled amino acids. Trends in isotope labeled amino acids can be observed by mass spectrometry and nuclear magnetic resonance (NMR) analysis. Therefore, Isotope labeled amino acids can be used as safe, effective, and convenient tracer tools for scientific research in medical, biological, pharmaceutical, and chemical fields.

The application scope of isotope-labeled amino acids is gradually infiltrating into various fields, such as life science, food and medicine, medicine, agriculture, environment, geology and so on. Stable isotope products are widely used in life sciences, such as metabonomics, protein genomics, clinical research, deuterated drug, and so on.


Fig 1 Proteins

Uses of Labeled Amino Acids:


--In The Field of Medicine: Isotope-labeled amino acids can be used for the clinical diagnosis of various diseases. By incorporating labeled amino acids into proteins, Labeled amino acids can be used as tracers to track the metabolic processes of amino acids and proteins in different physiological and pathological conditions, which allows the exploration of disease mechanisms and effective ways to prevent and treat diseases. This technique, known as metabolic labeling, has been used to investigate cancer metabolism, neurodegenerative diseases, and cardiovascular disorders.

--In The Field of Biology: Isotope labeled amino acids have become indispensable tools for studying protein dynamics and interactions. Isotope-labeled amino acids are used as starting materials to study the biosynthetic pathways and mechanisms of natural products in animals, plants, and microorganisms by analyzing the abundance of labeled elements in products. By introducing labeled amino acids into proteins, researchers can track their movement, folding, and binding to other molecules.

--In The Field of Pharmacy: Isotope-labeled amino acids are critical tools for the development of new drugs, and are used to determine the transfer, transformation, efficacy, mechanism of action, toxicity, and side effects of drugs in vivo. By incorporating labeled amino acids into drug candidates, researchers can track their distribution.

--In The Field of Chemistry: Incorporating labeled amino acids into chemical reactions allows chemists to track reaction pathways, identify reaction intermediates, and determine the stereochemistry of products. Isotope-labeled amino acids can be used as tracers to explore chemical reaction mechanisms and as raw materials for the synthesis of other labeled products, such as labeled polypeptides.


Product Description:


At ALL Chemistry, we are proud to offer a comprehensive range of Isotope labeled amino acids designed to meet the diverse needs of researchers in various scientific disciplines. These include free and protected amino acids as well as mixes and methyl labeling kits. The amino acids are available for different grades of material, with labeling accessible for different isotopic enrichments and patterns. Applications are directed to proteomic, metabolomic, metabolism, or structural biology studies. With precise isotopic labeling and rigorous quality control, our products ensure accurate and reliable results for your research.

ALL Chemistry has a perfect quality control system to ensure the high purity and isotope abundance of products throughout the process. We can not only provide a wide range of stable isotope products to help your scientific research, but also have an experienced team of experts in isotope synthesis that can provide scientists with professional, customized synthesis services for stable isotopes.

Product Advantage:


ALL Chemistry is an integrated supply platform for stable isotopes, which can supply chemicals with stable isotopes such as deuterium D, carbon 13, oxygen 18 and nitrogen 15.

ALL Chemistry can provide some stable isotope-labeled amino acids in stock, all products are provided with a quality analysis report (COA), and some products can provide NMR, MS, HPLC/GC spectra and detection methods.

ALL Chemistry provides isotopically labeled amino acid products with the advantages of high sensitivity, simple location and accurate quantification.

ALL Chemistry provides Isotope labeled amino acids with purity greater than 95%.

ALL Chemistry provides customized isotope-labeled amino acid services to meet your requirements.


Product Details:


ALL Chemistry can provide stable isotope-labeled amino acids in stock, and some product information is as follows:


Fig 2 N-Acetyl-DL-aspartic Acid-[2,3,3-d3]

Product Name: N-Acetyl-DL-aspartic Acid-[2,3,3-d3]

Chemical Formula: C6H6D3NO5

CAS Number: 89829-69-6

Purity: ≥95%

Description: N-Acetyl-DL-aspartic Acid-[2,3,3-d3] is a labeled N-acetyl-DL-aspartic acid. N-acetyl-DL-aspartic acid is a derivative of aspartic acid, which is a non-essential amino acid.


Fig 3 Betaine-[d9] Hydrochloride

Product Name: Betaine-[d9] Hydrochloride

Chemical Formula: C5H3D9ClNO2

CAS Number: 285979-85-3

Purity: ≥98%

Appearance: White powder

Solubility: Soluble in Water


Please contact us for further information, including pricing, samples, and technical specifications. We look forward to providing our isotope-labeled amino acid products. In addition, ALL Chemistry can provide synthesis and fine chemicals service if the existing products can't meet your needs, we expertise in synthesis of a broad array of customized molecules, and we offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.

Custom Chemical Synthesis is the process where a molecule is made exclusively for a particular client according to specifications at their scale. It is one of the options available for pharmaceutical companies requiring active pharmaceutical ingredients (APIs), intermediates, fine chemicals, reference standards, impurities or metabolites needed to launch their research and development projects. We provide a seamless one stop process development service, effectively speeding up the process of new drug development and reducing overall costs. Available documents for custom synthesis projects: synthesis report, high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance analyses (NMR), etc.

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