Bioactive Compound Library Service


Bioactive compounds are substances that can cause effects in the body and are one of the most important sources of drug discovery. Bioactive compounds have clear targets, act on specific target proteins in cells, participate in signal transduction, and regulate signal pathways. ALL Chemistry contains a large number of bioactive compounds, covering multiple targets and signal pathways, with a large number of compounds and strong structural diversity. All products are supported by literature, which is an important tool for drug high-throughput screening and high content screening.


Introduction of Bioactive Compound Library  


Natural bioactive compounds (NBCs) are gaining popularity because of their various medicinal properties and huge exploitation in various commercial sectors such as the food, chemical, and pharmaceutical industries. Bioactive compounds are "extranutritional" food constituents that typically occur in small quantities in foods and may have health benefits. Interest in them was sparked by the finding that plant extracts had protective effects on CVD and cancer. Bioactive compounds are molecules that can present therapeutic potential with an influence on energy intake while reducing pro-inflammatory states, oxidative stress, and metabolic disorders. Bioactive compounds might be degraded during food processing, particularly the heat-related process. Thus, the non-thermal process has been focused on as a potential technology to maintain and boost the bioactive compounds.

The library of bioactive compounds is a small molecule containing 40,000 known biological activities. These include some drugs that have been put on the market or are in the clinical stage, some classic active small molecules with clear targets, and some small molecules that have shown good biological activity in literature reports. Generally higher hit rates are observed in screening focused bioactive libraries when compared with the screening of diverse sets, and the hit clusters obtained from a successful focused library screening campaign usually exhibit discernible structure-activity relationships that facilitate follow-up of these hits. Focused Bioactive Libraries are a powerful tool for drug screening, cell induction, drug repurposing, mechanism research, target identification, positive control, and other related research fields. For example, a library containing more than 2,000 kinds of drugs on the market covers chemical drugs corresponding to various diseases on the market. These drugs have high biological activity diversity and chemical structure diversity and are a set of entry-level libraries with very high cost performance.


Classification of Bioactive Compound Library


Classification of disease types: Bioactive Compounds can be divided into compound libraries of different disease types according to their different indications or potential indications, such as anti-cancer compound libraries, anti-diabetes compound libraries, anti-infection compound libraries, anti-viral compound library and so on.

--Anti-cancer Compound Libraries: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy Metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients).

--Anti-diabetes Compound Libraries: Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar). Too much sugar in the blood for a long period can lead to serious health problems. If left untreated, diabetes can cause many complications that would seriously impact the quality of life and shorten the life expectancy of the people with it. Currently there is no known cure to diabetes but people with diabetes can stay healthy by managing their disease through diet and the help of medicine. A unique collection of 690 small molecules affecting the development of diabetes is an effective tool for diabetes research and drug screening.

--Anti-infection Compound Libraries: An infection happens when a foreign organism enters a person's body and causes harm. These infectious organisms are known as pathogens. Examples of pathogens include bacteria, viruses, fungi, prions, and Parasites. Some infections are mild and barely noticeable, but others are severe and life-threatening, and some are resistant to treatment. 

--Anti-viral Compound Library: Viruses can invade the body through various transmission routes, proliferate in host cells, and cause host damage. Common diseases include influenza, chickenpox and herpes, while diseases such as AIDS and polio are serious and life-threatening virus infections caused by HIV and poliovirus respectively.


Bioactive Compound Library at ALL Chemistry


ALL Chemistry can offer high-quality bioactive compound library services to scientists around the world. ALL Chemistry Bioactive Compound Library consists of a large number of small molecules with validated biological and pharmacological activities. As a powerful tool, bioactive compound libraries are very useful for small molecule discovery and new indication research. Bioactive compounds are used to customize the bioactive compound libraries for high-throughput screening (HTS) and high-content screening (HCS). You can customize compounds, quantities, format (dry or solid, DMSO or other buffers), and plate layout (Such as Cell Signaling pathways, Clinical research, and Targets) to meet your specific requirements.


Fig.1 96-well format sample storage tube


Advantages of Our Services


-- NMR and HPLC are validated to ensure high purity and quality. All compounds are in stock and continuously updated.

-- A large number of compounds are used for high-throughput screening (HTS) and high-content screening (HCS).

-- The structure is diverse, the drug effect is remarkable, and it can penetrate cells.

-- Bioactivity and safety are confirmed by preclinical research and clinical trials. Some have been approved by FDA.

-- More detailed compound information with structure, IC50, and other chemical & biological data.

-- Have a fully detailed structural description and customer feedback information.

-- Widely used in the research focus areas such as Cancer, Stem Cell, Neuronal Signaling, Immunity, and more.


Project Workflow


Evaluation → Experiment Design → Formal Quotation → Bioactive Compound Library Service → Results → Delivery


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