Custom Peptide Library Construction


ALL Chemistry has the capability to custom any Peptide Library Construction at customers' request. Our scientists have accumulated extensive experience in different types of Peptide Library Construction. Peptide library is helpful to do new drug research and development.


Introduction of Custom Peptide Library


Peptide Libraries are systematic combinations of a large variety of peptides, many peptide libraries are produced on a solid backing such as resin or beads. They can also be supplied in vials or tubes. There are at least five subtypes of synthetic peptide libraries that differ from each other by the method that was used for the synthesis of the library. These are (a) overlapping peptide libraries, (b) truncation peptide libraries, (c) random libraries, (d) alanine scanning libraries and (e) positional or scrambled peptide libraries. Peptide libraries can be prepared by companies that specialize in working with peptides and other biological materials, and they can also be made in the lab, at a lab that has the ability to synthesize peptides. Many researchers order their peptide libraries from companies that specialize in their production, with many companies being able to fill orders extremely quickly.

Many labs can supply custom peptide libraries by request. These can be tailored for a specific purpose, and may include an array of specific peptides. Random libraries are also available. The peptide library usually comes with documentation clearly describing each peptide in the collection, so that people know what they have to work with. This documentation may also include a discussion of the methods used to generate the library, as this information can be important for researchers to have, especially if they are publishing research conducted with the assistance of the peptide library. The peptide library can be used in a wide range of research applications where people want to work with various combinations of amino acids. The cost of the library varies, depending on what kind of library it is and how many peptides are involved.



Fig.1  Peptide Library


Applications of Custom Peptide Library


--Peptide Screening: Custom peptide libraries are extensively used in screening experiments to identify peptides with desired properties. These libraries allow researchers to screen a vast number of peptides simultaneously, saving time and resources. Peptide screening can be applied to various research areas, including drug discovery, protein-protein interactions, enzyme-substrate interactions, and receptor-ligand interactions.

--Identify Specific Peptides: Custom peptide libraries enable the identification of specific peptides that can be used for various purposes. For example, researchers can use these libraries to identify peptides that bind to specific targets, such as disease-related proteins or receptors. These specific peptides can then be further studied to understand their binding mechanisms, develop therapeutic agents, or design diagnostic tools.

--Drug Development: Custom peptide libraries play a vital role in drug development. Peptides can serve as potential drug candidates or be used to design peptide-based drugs. By screening large peptide libraries, researchers can identify peptides that exhibit desired biological activities, such as inhibiting enzymes, blocking protein-protein interactions, or modulating signaling pathways. These identified peptides can then be further optimized and developed into therapeutic drugs.

--The Purification of Proteins: Peptide libraries are also utilized in protein purification techniques. By immobilizing proteins of interest onto solid supports, researchers can use custom peptide libraries to identify peptides that bind specifically to the target protein. These binding peptides can then be used to purify the protein from complex mixtures.

--Vaccines Development: Custom peptide libraries are instrumental in the development of vaccines. Peptides derived from pathogens or disease-related proteins can be synthesized in libraries and screened for their ability to induce an immune response. Custom peptide libraries provide a powerful tool for the discovery and development of peptide-based vaccines, offering potential solutions to combat various diseases.

--Epitope Mapping: Epitope mapping, the process of identifying the specific regions of antigens recognized by antibodies or immune cells, is another crucial application of custom peptide libraries. By synthesizing overlapping peptides derived from a target antigen, researchers can screen these libraries with antibodies or immune cells to identify the precise epitopes responsible for immune recognition.


Custom Peptide Library Services at ALL Chemistry


The synthetic peptide library consists of a peptide fragment of a specific length which contains various possible sequences or most sequences of the short peptide of this length. The synthetic peptide library family includes a random synthetic peptide library, a synthetic peptide combinatorial library (SPCL), a multi-purpose peptide library (MUPL), a position-synthesized synthetic peptide combinatorial library (PS. SPCL), an oligonucleotide-encoded synthetic peptide library, and the like. Scientists at ALL Chemistry continuously strive to produce high-quality Custom Peptide Library Construction and related services to solve problems in scientific discovery.

ALL Chemistry provides a variety of peptide libraries for the separation of minimal-length active peptide sequences, identification of critical amino acid residues, design of sequence-optimized analogs, etc. For protease and kinase studies, we also supply peptide microarrays. Meanwhile, we provide relevant analytical services to meet customer needs. In addition to its use in protein research and molecular recognition, peptide library technology is also used in immunology, such as epitope analysis, drug design, and vaccine development. The classification details of the customized peptide library construction services we can provide are as follows:


Alanine Peptide Scanning Library Construction

Overlapping Peptide Library Construction

Positional Peptide Library Construction

Random Peptide Library Construction

Scrambled Peptide Library Construction

Truncation Peptide Library Construction


Besides, ALL Chemistry has developed a peptide library based on phage display technology that allows you to screen targets of interest from a billion combination pools in an extremely efficient way. We also provide our customers with modified peptides with different tags, including isotope labels, fluorescent dye, phosphorylation, glycosylation, N-Methyl amino acids, O-sulfonation, cyclic peptides and fluorophores. Please feel free to contact us to get more information about Custom Peptide Synthesis & Modification Services.


Advantages of Our Services


Low Cost, Rapidity and Easy Operability.

Accuracy, Visibility and Easy Analysis.

Competitive Prices: Our peptide library services are the most cost-efficient on the market.

Flexible Purity Choices: Crude, desalt, >70%, >75%, >80%, 85%, >90%, >95%, and >98% purity are available to meet your multiple demands.

No Cross-contamination: Peptides are supplied in individual well labeled vials.

Comprehensive Modifications: Our modification service includes labeling, the incorporation of unnatural amino acids, and peptide cyclization with disulfide bridges.

Stringent Quality Control: ALL Chemistry provides MS and HPLC validation data for each peptide.

Chemistry provides epitope mapping service, binding assay, and functional assay services for your drug discovery research.


Project Workflow


Evaluation → Experiment Design → Formal Quotation → Custom Peptide Library Construction → Results → Delivery


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