Trametinib

Datasheet MSDS
Catalog Number
A2125
Product Name
Trametinib
Structure
Trametinib
CAS Number
871700-17-3
Synonyms
JTP-74057, GSK1120212
Molecular Formula
C26H23FIN5O4
Molecular Weight
615.39
Purity
99.88%
Solubility
DMSO: 21 mg/mL (34.1 mM) Ethanol: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition for more than 180 kinases, including B-Raf, c-Raf, and MEK5.
Target
MEK1 MEK2
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