The Introduction of Labeled APIs:
API, also known as active pharmaceutical ingredient, refers to any substance or mixture of substances used in the manufacture of pharmaceuticals. APIs are crucial in the pharmaceutical industry as they form the basis of drug formulation and development. These substances undergo rigorous research, testing, and regulatory scrutiny to ensure their safety and efficacy for human use. Generally speaking, after adding excipients and processing, APIs can be made into medicines that can be used directly. APIs can be derived from natural sources, synthesized through chemical processes, or produced using biotechnological methods. Once an API is developed, it is combined with other inactive ingredients to create a final pharmaceutical product, such as tablets, capsules, or injectables. Applications for APIs include oncology, diabetes, cardiovascular disease, central nervous system and neurological disorders, endocrinology, and more. APIs are the active ingredients in pharmaceutical drug that provide the desired therapeutic effect. They undergo rigorous testing and quality control to ensure their safety and efficacy. APIs form the backbone of drug development and play a vital role in improving healthcare outcomes for patients worldwide.
Isotope-labeled APIs involve the use of isotopically labeled compounds in scientific research and analysis. Isotopes are atoms of the same element that have different numbers of neutrons, resulting in variations in their atomic mass. Isotope-labeled API is a chemical reagent that contains one or several isotopic atoms in the molecule, and uses its traceability for analytical determination. The chemical properties of the reagents replaced by isotopes are usually unchanged except for isotopic effects. Isotope labeling is a technique widely used in fields such as molecular biology, metabolomics, proteomics, and drug discovery. Isotope-labeled reagents can participate in similar chemical reactions and are widely used as tracers to study the laws of substance movement and change. The use of isotope-labeled APIs offers numerous advantages in scientific research. It enables researchers to accurately measure and quantify the presence of labeled compounds, track their movement within biological systems, and gain insights into metabolic pathways, protein interactions, and cellular processes.
Principles of Isotope Labeling:
Radionuclides (or stable nuclides) and their compounds used in isotope tracing have the same chemical and biological properties as the corresponding common elements and their compounds existing in nature, but they have different nuclear physical properties. Therefore, isotopes can be used as a marker to make labeled compounds containing isotopes (such as labeled foods, drug and metabolites) instead of corresponding unlabeled compounds. Using the nuclear physical properties of radioactive isotopes that constantly emit characteristic rays, we can track its position, quantity and transformation in vivo or in vitro at any time with nuclear detectors. Although stable isotopes do not release rays, they can be determined by mass analysis instruments such as mass spectrometers, gas chromatographs, and nuclear magnetic resonance. Both radioactive isotopes and stable isotopes can be used as tracers. However, as tracers, stable isotopes have low sensitivity, few available types, and high prices, and their application scope is limited. Using radioisotope as a tracer is not only sensitive but also simple and easy to measure, which can accurately quantify, accurately locate, and meet the physiological conditions of the studied object.
Product Description:
Isotopes can be used to track the movement and change of substances. With the help of isotope atoms, the organic reaction process can be studied. Scientists can find out the detailed process of chemical reaction by tracing the compounds labeled by tracer elements. This scientific research method is called isotope labeling.
ALL Chemistry is committed to providing customers with isotope-labeled APIs. Our products come with comprehensive analytical data files and are of high chemical purity. With ALL Chemistry's isotope labeled APIs, researchers can explore organic synthesis, drug discovery, environmental analysis, and many other fields.
To sum up, ALL Chemistry's range of isotope labeled APIs provides researchers with powerful tools to advance their scientific endeavors. ALL Chemistry can provide the isotope-labeled APIs with high purity, stability and customization, so as to accurately track and locate them in the scientific research process.
Product Advantage:
Optimal Prices: Buying products on this site guarantees the best price.
Quality Assurance: Each compound undergoes rigorous testing, guaranteeing consistent and reproducible results.
One-to-one Customization: Researchers can choose specific isotopes, labeling positions, or other modifications to tailor the compounds to their specific experimental needs.
Diversified Products: ALL Chemistry's products include a diverse range of isotope labeled APIs, covering a wide array of chemical classes and functionalities. From small organic molecules to complex natural products, we provide an extensive selection.
Technical Support: ALL Chemistry's team of experts is committed to providing exceptional customer support. We offer technical assistance and guidance in selecting the appropriate isotope labeled APIs for your research.
Product Details:
ALL Chemistry can provide stable isotope-labeled APIs in stock, and some product information is as follows:
Fig 1 Lamotrigine-13C-D3
Product Name: Lamotrigine-13C-D3
Chemical Formula: C8[13C]H4Cl2N5D3
CAS Number: 1246815-13-3
Purity: ≥95%
Appearance: Off-White to Pale Yellow Solid
Solubility: DMSO (Slightly), Methanol (Slightly)
Fig 2 Varenicline-d4
Product Name: Varenicline-d4
Chemical Formula: C13H9N3D4
CAS Number: 2183239-01-0
Purity: ≥98%
Please contact us for further information, including pricing, samples, and technical specifications. We look forward to providing our isotope-labeled APIs products. In addition, ALL Chemistry can provide synthesis and fine chemicals service if the existing products can't meet your needs, we expertise in synthesis of a broad array of customized molecules, and we offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.
Custom Chemical Synthesis is the process where a molecule is made exclusively for a particular client according to specifications at their scale. It is one of the options available for pharmaceutical companies requiring active pharmaceutical ingredients (APIs), intermediates, fine chemicals, reference standards, impurities or metabolites needed to launch their research and development projects. We provide a seamless one stop process development service, effectively speeding up the process of new drug development and reducing overall costs. Available documents for custom synthesis projects: synthesis report, high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance analyses (NMR), etc.
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