Compound screening is the process of selecting higher-activity compounds for a specific target from a large number of compounds or new compounds through standardized experimental methods. Its essence is the process of experimenting with compounds for pharmacological activity. Now most pharmaceutical companies perform Compound Library Screening during the drug development process by using vast compound libraries to identify potential targets. About thousands of data points are required in searching for an inhibitor that could potentially become a drug. Hence, high-throughput screening (HTS) has become essential in this process. HTS is a high-tech way to hasten the drug discovery process, allowing quick and efficient screening of large compound libraries at a rate of a few thousand compounds per day or per week.
Virtual Drug Screening, a method used to narrow down search for potential drugs by running computer simulations of drug-target interactions, works by large scale predicting native-like protein-ligand complexes (PLC) from an abundance of docking decoys. It provides possible drug candidates, facilitating early-stage drug discovery.
ALL Chemistry Inc. can quickly conduct thousands of experiments to identify 'hits' for appropriate biological responses through the use of automated robotics, liquid handling, imaging, and data analysis systems. By using modern screening technology, ALL Chemistry Inc. assists our global customers in drug research and development, thereby accelerating the process of drug innovation.
*High-Throughput Screening (HTS)
*Virtual Drug Screening
Fig 1 Compound screening
Fig 2 Diagrammatic illustration of preponderance of drug screening platform by iPSC-induced cardiomyocytes.[1]
ALL Chemistry Inc. aims to provide global customers with professional custom solutions. If you are interested in our services, please contact us. Our R&D scientists will make a detailed plan and technical support manager will prepare a quotation for you.
References
[1] Wang, P., et al., Merits of hiPSC-Derived Cardiomyocytes for In Vitro Research and Testing Drug Toxicity. Biomedicines, 2022. 10: p. 2764.
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