Asymmetric synthesis, also known as chiral stereoselective synthesis or enantioselective synthesis, is a method for preparation of chemical compounds which aims to bias the synthesis in favour of producing one stereoisomer over another stereoisomer. Asymmetric synthesis plays a very important role in drug synthesis and total synthesis of natural products, since different enantiomers often interact with the target biological receptors very differently and often with different responses. Whereas, it is difficult to obtain two enantiomers in unequal amounts. Hence it is essential to establish a condition, where the energies of activation for the formation of two enantiomers are unequal during the asymmetric synthesis. Many examples have been studied, showing that dissymmetric influence for the production of diastereomeric transition states can be achieved by the use of a chiral reagent, a chiral catalyst, a chiral solvent or by carrying out the reaction under the influence of any one component of circularly polarised light.[1][2]
ALL Chemistry Inc. offers four chemical strategies for enantioselective synthesis: Chiral pool synthesis, Asymmetric induction, Chiral resolution and Asymmetric catalysis. ALL Chemistry Inc.'s experts provide multi-step synthesis from a few milligrams up to metric tons and full R&D analytical services for in-process and final active compounds. Additionally, ALL Chemistry Inc. has an extensive list of chiral products in development, which can normally be offered from gram scale to multi-kilo scale. And we add new chiral synthons at regular intervals, for applications in asymmetric synthesis and as "building blocks" or intermediates in pharmaceutical chemistry.
Our Capabilities
l Chiral pool synthesis
l Enantioselective catalysis
ü Biocatalysis (Enzymatic reactions)
ü Enantioselective organocatalysis
l Asymmetric induction
l Chiral auxiliaries
Separation and Analysis Technologies
l HPLC
l GC
l SFC
l CLEC
l NMR
l MIT
l Others
ALL Chemistry Inc. aims to provide global customers with professional chemical products and custom solutions. If you are interested in our products or services, please contact us. Our R&D scientists will make a detailed plan and the technical support manager will prepare a quotation for you.
References
[1] Karnik, A.V. and M. Hasan, Chapter 10 - Diastereomeric transition states and stereoselectivity, in Stereochemistry, A.V. Karnik and M. Hasan, A.V. Karnik and M. Hasan^Editors. 2021, Elsevier. p. 407-463.
[2] Kumar, D.K., CHIRAL SYNTHESIS: AN OVERVIEW. International Journal of Pharmaceutical Research and Development, 2014. 6: p. 70.
+1 609 531 0668
info@all-chemistry.com
STE 104 Marlton , NJ 08053, USA