A revolutionary discovery of the unique property of double-stranded RNA (dsRNA) to silence gene expression in the nematode worm Caenorhabditis elegans cast its spell on the scientific community in biotechnology field. This phenomenon, called RNA interference (RNAi), provides us with a way to fight many diseases that are difficult to cure with conventional therapies, thereby greatly enriching the technical means of gene therapy. Polymer-mediated siRNA delivery is a method of delivering small interfering ribonucleic acid (siRNA) molecules to target cells in order to silence or reduce the expression of specific genes. This delivery method utilizes a polymer to bind the siRNA and facilitate its entry into the target cell. This method has been used as a therapeutic approach to treat a variety of diseases, including cancer. Polymer-mediated siRNA delivery has several advantages such as facile chemical modifications, good biocompatibility, multifunctionality, fusion with inorganic materials which can address various impediments associated with efficient siRNA delivery. Integration of various functionalities into polymeric siRNA delivery systems could have profound impacts on biomedical research and promise to revolutionize the wider spectrum of therapeutic field in curing many debilitating afflictions of mankind.[1]
In order to obtain good clinical treatment results, ALL Chemistry Inc. can customize polymer delivery systems for customers, and we have the following polymer-carriers for you:
· Polyethylenimine(PEI)
Polyethylenimine is a polymeric compound with a high molecular weight that is used as a cationic polymer in a variety of applications, including medical, industrial, and research. It is a polyamine-based polymer with a primary amine group, which is why it is used as a cationic polymer. Polyethylenimine has excellent adsorption properties, making it a good choice for adsorbing small molecules and other materials. It is also highly soluble in water, making it ideal for use in aqueous solutions. Polyethylenimine is often used as a stabilizing agent, a chelating agent, and a cross-linking agent in a variety of products.
· Poly(dl-lactide-co-glycolide)
PLGA is a copolymer of glycolic acid (GA) and lactic acid (LA) linked together by ester bonds. We can control the degradation rate of PLGA by adjusting various parameters such as LA / GA ratio, MW and structural polymer matrix. Based on these characteristics, we have developed PLGA nanoparticles (NPs) as carriers of RNAi delivery, which have the advantages of small particle size, high safety and sustained release.
· Chitosan
For decades chitosan has been drawing immense application in diversified areas especially in pharmaceutics. The versatility of chitosan in its native or functionalized form stems from its high natural abundance, nonallergenicity, biocompatibility, and biodegradability. In addition to these favorable features the cationic property makes chitosan derivatives a potent vector for nucleic acids.
· Cyclodextrin
· Polypeptides
· Dendrimers
· Nanogel
· Nanomaterial-Mediated siRNA Delivery Vectors
References
[1]Singha K, Namgung R, Kim WJ. Polymers in small-interfering RNA delivery. Nucleic Acid Ther. 2011 Jun;21(3):133-47.
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