Natural molecules tend to be multi-active across targets being inherently bio-available. The value of the library is in broad diversity representation of selected natural material available in screen-ready format. ALL Chemistry will provide a natural product library to qualified customers through customized synthesis services after defining the use of your products.
Introduction of Natural Compound Library
For thousands of years, nature has been the source of drugs, and a large number of modern drugs have been separated from nature, many of which are based on their uses in traditional medicine. With the development of compound targets, there is an increasing demand for screening compound diversity. Through the continuous study of natural biodiversity, many of them are still to be developed, and natural products will play a key role in meeting this demand. According to literature reports, in the era of traditional drug research and development, natural products were the most important and almost unique source of new drug research and development. With the development of organic chemistry, medicinal chemistry, computer technology and so on, it is still one of the important means of new drug research and development to transform or design new compounds based on the mother nuclear structure of natural products, even today when synthetic small molecular drugs are dominant.
Fig.1 Percentage of natural products/analogues in drugs approved for marketing
(https://baijiahao.baidu.com/s?id=1740665704182746598&wfr=spider&for=pc)
Among the small molecular drugs that have been approved for marketing, drugs derived from natural products or their derivatives can still occupy half of the country. Natural products are small molecular compounds produced in nature, from any organism, including primary metabolites and secondary metabolites. Natural products have potential biological activities and can be used as lead compounds for drug discovery and commercial development. It is one of the main ideas of developing new drugs based on natural products to optimize their physical and chemical properties (improving solubility, stability, etc.) and biological activities (improving selectivity, reducing toxicity, etc.) by transforming the original structure of natural products or chemically modifying their mother nuclei, so as to obtain a series of natural product derivatives with better medicinal properties. For example, Rosuvastatin is a new type of hypolipidemic drug inspired by the natural extract of Penicillium Mevastatin.
Fig.2 Rosuvastatin-Penicillium natural extract analogue
(https://baijiahao.baidu.com/s?id=1740665704182746598&wfr=spider&for=pc)
Classification of Natural Compound Library
Natural product libraries can be classified according to their structures, such as flavonoids, terpene, alkaloids and phenols.
--Flavonoid Compound Library: Flavonoids are a ubiquitous group of naturally occurring polyphenolic compounds characterized by the flavan nucleus and represent one of the most prevalent classes of compounds in fruits, vegetables and plant-derived beverages. Flavonoids are now known to be ubiquitous in many plants, including the onion (Allium cepa) skin is used as a hay-fever remedy and a digestive anti-inflammatory, and is the active ingredient in a popular OTC nasal spray for sinusitis and allergies. Flavonoids are water-soluble phenolic compounds (having a -OH group attached to an aromatic ring) and are found in the vacuoles of plant cells. Quercetin and rutin are among the most largely found flavonoids in a great variety of fruits and vegetables, including tea, coffee, and other grains.
--Terpene Compound Library: Terpenes are a large and diverse class of organic compounds, produced by a variety of plants, particularly conifers, and by some insects. They are also called isoprenoids—are made up of isoprene molecules. The building block is a five-carbon isoprene (CH2C(CH3)CHCH2) unit . Herbs and higher plants containing their oxidized derivatives, known as terpenoids. Terpenoids are the largest group of phytochemicals consisting of several diverse compounds that are highly diverse in chemical structure, and are a rich reservoir of candidate compounds for drug discovery. Most terpenoids are multicyclic structures that differ from one another not only in functional groups but also in their basic carbon skeletons.
--Alkaloid Compound Library: Alkaloids are groups of natural occurring simple or complex, low molecular weight nitrogen containing compounds which are basic in nature. Alkaloids are secondary metabolites abundantly found in plants, but also to a lesser extent in microorganisms (bacteria and fungi) and animals. In general, a given species contains only a few kinds of alkaloids, though both the opium poppy (Papaver somniferum) and the ergot fungus (Claviceps) each contain about 30 different types. Certain plant families are particularly rich in alkaloids; all plants of the poppy family (Papaveraceae) are thought to contain them. Alkaloids have a wide range of pharmacological activities, including antimalarial, antiasthmatic, anticancer, cholinergic, vasodilator, antiarrhythmic, analgesic, antibacterial and antidiabetic activities.
--Polyphenolic Compound Library: Polyphenols are compounds with various potential biological properties such as antioxidants, anti-inflammatory, antineoplastic, antiaging, cardioprotective, anticancer, and antimicrobial properties. Natural polyphenols play an important role in cancer prevention and treatment by blocking cell cycle, inducing Apoptosis, and inhibiting cell adhesion, migration, proliferation, and differentiation. Polyphenols are defined as compounds having at least one aromatic ring with one or more hydroxyl functional groups attached. Natural polyphenols include flavonoids, phenolic acids, lignans, tannins, stilbenes, curcumin, Coumarin, quinone, and other polyphenols.
Natural Compound Library at ALL Chemistry
Natural products originate from various sources, including animals, plants, microorganisms, etc. With their diverse structures, natural products cover over 30 types of unique compound structures, including flavonoids and alkaloids, and exhibit various biological activities such as anti-cancer and anti-inflammatory characteristics. ALL Chemistry contains kinds of natural products. We created several Characteristic Natural Product Libraries based on their biogenesis and the source they originate from as well as their specific applications (Anti-Inflammatory Traditional Chinese Medicine Compound Library, Anti-Tumor Natural Product Library, and Food as Medicine Compound Library).
Natural products are known for their general high bioactivity and representative chemical backbones. ALL Chemistry has built a collection of Natural Product Libraries that can be used for CADD. The libraries comprise a leading number of natural products and their derivatives. By implementing CADD to in-house compound screening, we believe new drug discovery would be more efficient and cost-effective. The ALL Chemistry natural product libraries are continuously updated, and our natural product libraries can be used for high-throughput screening, high-content screening, new drug development, pharmacological research and other fields. We will provide a library of ALL Chemistry natural products to qualified customers through customized synthesis services after defining the use of your products, and we will provide solution packaging or powder packaging for all products in the library.
Advantages of Our Services
-- Lower price with higher quality, saving scientific research funds.
-- A useful tool for drug discovery as an important source of lead compounds.
-- NMR and HPLC validated to ensure high purity and quality. All compounds are in stock and continuously updated.
-- A large number of compounds are used for high-throughput screening (HTS) and high-content screening (HCS).
-- The structure is diverse, the drug effect is remarkable, and it can penetrate cells.
-- Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
-- More detailed compound information with structure, IC50, and other chemical & biological data.
-- Have a fully detailed structural description and customer feedback information.
-- Widely used in the research focus areas such as Cancer, Stem Cell, Neuronal Signaling, Immunity, and more.
Project Workflow
Evaluation → Experiment Design → Formal Quotation → Custom Natural Compound Library Service → Results → Delivery
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