The Introduction of Natural Compounds:
Natural products refer to the constituents or metabolites of animals, plant extracts (abbreviated as plant extracts) or insects, marine organisms, and microorganisms, as well as many endogenous chemical components in humans and animals, collectively referred to as natural products. General natural compounds have specific molecular formulas, structural formulas, and single chemical and physical properties. In percentage terms, the collection can be said to comprise 30–35% of strictly natural compounds isolated from plants, microorganisms, marine species, etc.; approximately 40% are derivatives of natural compounds, i.e., modified alkaloids, terpenoids, flavonoids, etc.; and the remaining 25–30% are mimetics (analogs) of the strictly natural compounds, e.g., azosteroids, azocoumarins, conjugated isoindole systems, oxaterpenoids, etc.
Natural Products have a great deal of structural diversity. Compared to the typical synthetic small drug-like molecules, natural products tend to have more sp3-hybridized bridgehead atoms, more chiral centers, a higher oxygen content but a lower nitrogen one, a higher molecular weight, a higher number of H-bond donors and acceptors, lower cLogP values, higher molecular rigidity, and preferably aliphatic rings over aromatic ones.
Natural products have been used for disease treatment and healing since ancient times. They have obviously become an inspiration for modern medicinal chemistry, drug discovery, and drug development. Approximately 40% of the drugs approved by the FDA during the last decade were natural products, their derivatives, or synthetic mimetics related to natural products. Nowadays, new drugs based on natural compounds are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders.
Fig 1 Natural Compounds
Classification of Natural Compounds:
Natural compounds mainly come from organisms, and the compounds are classified into four different groups according to their biosynthetic origin: alkaloids, phenylpropanoids, polyketides, and terpenoids.
--Alkaloids: The Term alkaloids means the ashes of plants. Alkaloids are groups of naturally occurring, simple or complex, low-molecular-weight nitrogen-containing compounds that are basic in nature. Alkaloids are produced by many organisms, such as bacteria, fungi, plants, and animals. Alkaloids are secondary metabolites abundantly found in plants but also, to a lesser extent, in microorganisms (bacteria and fungi) and animals. Alkaloids have diverse and important physiological effects on humans and other animals. Alkaloids have a wide range of pharmacological activities, including antimalarial, antiasthmatic, anticancer, cholinergic, vasodilator, antiarrhythmic, analgesic, antibacterial, and antidiabetic activities. Many drugs have been used in traditional or modern medicine, and some have become the starting point of drug discovery.
--Phenylpropanoids: The phenylpropanoids are a family of organic compounds that are synthesized by plants from the amino acids phenylalanine and tyrosine. The general phenylpropanoid metabolism generates an enormous array of secondary metabolites based on the few intermediates of the shikimate pathway as the core unit. Phenylpropanoids are characterized by their unique aromatic structures, consisting of a phenyl ring attached to a three-carbon propene side chain. Phenylpropanoids are widely distributed in the plant kingdom and are important components of many structural polymers. Phenylpropanoids are known to have multifaceted effects that include antimicrobial, antioxidant, anti-inflammatory, antidiabetic, and anticancer activities, as well as renoprotective, neuroprotective, cardioprotective, and hepatoprotective effects.
--Polyketides: Polyketides are bioactive natural products isolated from diverse microorganisms. Although only a limited number of these antibiotics have been isolated over the past half-century by conventional screening methods, new genomic technologies have provided compelling evidence that the biosynthetic potential for structurally diverse polyketides in nature is truly immense. Polyketides (PKs) are compounds with antimicrobial activity, which also have clinically important applications. Many polyketides are biologically active as antibiotics, anticancer agents, and immunosuppressants, and are pharmacologically important products.
--Terpenoids: Terpenoids are the largest group of phytochemicals, consisting of several diverse compounds that are highly diverse in chemical structure and are a rich reservoir of candidate compounds for drug discovery. Terpenoids are ubiquitous; thus, they are found in almost all classes of living organisms. They contribute to the flavor, scent, and color of plants’ leaves, flowers, and fruits. Terpenoids show a range of pharmacological activities, such as anti-viral, hypoglycemic, anti-bacterial, anti-malarial, anti-inflammatory, and anti-cancer activities. Terpenoids are also essential for plant growth and development. Whereas in animals, terpenoids serve as the precursors of steroids and sterols.
Product Description:
Natural products are not only the active ingredients of most traditional medicines, but also the active ingredients of many modern medicines. ALL chemistry is dedicated to providing researchers with high-quality, bioactive natural compounds derived from diverse sources, such as plants, marine organisms, and microorganisms. Furthermore, since the structural diversity of natural products exceeds the structural diversity that can be easily achieved by chemical synthesis, and synthetic analogs with improved efficacy and safety can be prepared, natural products are often used as a starting point for drug discovery. Natural compounds offer a promising avenue for discovering new therapeutic agents due to their diverse chemical structures and biological activities.
The most representative classes include various types of alkaloids, terpenoids, flavonoids and coumarins, peptides, glycosides, and nucleosides, and phenol compounds. The collection is also rich in rare and unusual compounds. Apart from this, ALL Chemistry also has a collection of functionalized natural compounds that can be used in Natural Combinatorial Chemistry as natural matrices. Our natural compounds for ALL chemistry have been meticulously selected and rigorously characterized. With our products, researchers can trust that they are working with reliable and reproducible compounds, allowing them to focus on their research objectives.
ALL Chemistry provides more than 10,000 kinds of natural compounds that can meet the different needs of clients. The main types of products include alkaloids, phenylpropanoids, polyketides, and terpenoids, which are classified in detail as follows:
Please contact us for further information if you have a purchase requirement, including pricing, samples, and technical specifications. We look forward to providing our natural compound products. In addition, ALL Chemistry provides a seamless one-stop process development service, ALL Chemistry can provide synthesis and fine chemical services if the existing products can't meet your needs, we have expertise in the synthesis of a broad array of customized molecules, and we offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.
Product Advantage:
Provide quality-guaranteed products, all products are provided with a quality analysis report (COA), use advanced instruments such as MS(Mass Spectrometry), HPLC and NMR (Nuclear Magnetic Resonance) for quality inspection.
Professional and reliable packaging ensures the safety and stability of products from transportation, storage to use.
ALL Chemistry provides natural compound products with a purity greater than 90%.
ALL Chemistry guarantees the confidence to put our products in a risk-free environment for worldwide scientists and researchers.
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