Labeled Products - ALL Chemistry-Custom Chemical Solutions Supplier

Labeled Products

The Introduction of Labeled Compounds:

Stable Isotopes are stable isotope compounds, ranging from gases to complex molecules. These compounds are useful for tracer studies in proteomics and metabolomics, agents for MRI/ MRS, and a wide range of other biomedical applications. Both tracer and flux studies benefit from stable isotope label assistance. Metabolic pathways can be studied by tracking naturally occurring and disease-indicated metabolites. Additionally, the effects of exogenous substances or perturbations on the metabolome can be elucidated with the use of our stable isotope-labeled internal standards coupled with mass spectroscopy determination.

An isotopically labeled compound in which one or more atoms are replaced by isotopes or other easily recognizable nuclides. This substitution process is called isotope labeling. The isotope labeling method is a micro-analysis method that uses radionuclides as tracers to label the research object; that is, by adding radioactive isotope atoms to other substances, making them move and migrate together, and then tracking them with radioactive detection instruments, we can know what path the radioactive atoms took, where they moved, and how they were distributed.

Radionuclides (or stable nuclides) and their compounds used in isotope labeling have the same chemical and biological properties as the corresponding common elements and their compounds existing in nature, but they have different nuclear physical properties. Therefore, isotopes can be used as a marker to make labeled compounds containing isotopes instead of corresponding unlabeled compounds. Using the nuclear physical properties of radioactive isotopes that constantly emit characteristic rays, we can track their position, quantity, and transformation in vivo or in vitro at any time with nuclear detectors. Although stable isotopes do not release rays, they can be determined by mass analysis instruments such as mass spectrometers, gas chromatographs, and nuclear magnetic resonance. Isotope labeling has the characteristics of a simple method, accurate location and quantification, and accordance with physiological conditions.

Fig Stable Isotope Labeled Amino Acids

Uses of Labeled Compounds:

Isotopic-labeled compounds have played an important role in many fields because of their unique properties and applications.

--Environmental: Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food. Specifically speaking, stable isotopes, such as Carbon-13 and Nitrogen-15 are used to trace the movement of elements and nutrients through ecosystems.

By analyzing the isotopic composition of various organisms and their surroundings, scientists can determine food webs, migration patterns, and nutrient cycling. Isotope labeling provides a powerful tool for understanding ecological processes and the impact of human activities on the environment.

--Clinical diagnostic: In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening. Isotopes are incorporated into specific compounds that target particular organs or tissues in the body, enabling the visualization and diagnosis of various diseases and conditions. The use of stable isotope compounds in medical imaging, in conjunction with 13C-MRS in vivo techniques, provides a method to explore fluxes through energy-related metabolic pathways for early diagnosis and treatment of neuropsychiatric disorders, cancer, and other diseases. Isotope-labeled compounds have revolutionized medical imaging by providing accurate and detailed information about physiological processes within the body.

--Organic Chemistry: Isotope labeling also plays a vital role in studying chemical reactions and mechanisms. By introducing isotopes into reactants or products, we can trace the movement and transformation of atoms during a reaction. Small-molecule compounds labeled with stable isotopes can be used as chemical references for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds. Isotopic tracing helps elucidate reaction mechanisms, leading to the development of more efficient and selective synthetic routes.

--Metabolic Research: Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner. The use of our stable isotope-labeled compounds in metabolic and nutritional studies provides a means to dissect biochemical pathways. The availability of isotope-labeled compounds for basic scientific research permits the examination of the role of metabolic pathways in maintaining physiological states. In vivo studies using stable isotope labeled metabolites reveal important aspects of metabolism, including pathways and flux.

Product Description:

The key to stable isotope-labeled compound technology lies in the quality of stable isotope-labeled compounds used in synthetic products. In order to provide high-quality stable isotope-labeled compounds, ALL Chemistry has reached a strategic cooperation agreement with isotope-labeled manufacturers to ensure that we can provide all kinds of isotope-labeled products with stable quality. All Chemistry has a professional team, mature technology and purification technology, a rigorous working attitude, and strict quality requirements. All products come with high chemical purity.

ALL Chemistry offers a complete range of labeled compounds with stable quality, and our custom compounds labeled with stable isotopes include 2H (deuterium), 15N, 13C. We provide labeled compounds of high quality at a low price to all companies or institutions with quality control. According to customer requirements, provide corresponding isotope-labeled compound products. We will adhere to the business philosophy of customer first, trying our best to meet customers' requirements for different purity isotope-labeled compounds.

Product Advantage:

ALL Chemistry is an integrated supply platform for stable isotopes, which can supply chemicals with stable isotopes such as deuterium D, carbon 13, oxygen 18 and nitrogen 15.

ALL Chemistry can provide some stable isotope-labeled compounds in stock, all products are provided with a quality analysis report (COA), and some products can provide NMR, MS, HPLC/GC spectra and detection methods.

ALL Chemistry provides isotope-labeled compound products with the advantages of high sensitivity, simple location and accurate quantification.

ALL Chemistry provides isotope-labeled compounds with purity greater than 95%.

ALL Chemistry provides customized isotope-labeled compound services to meet your requirements.

ALL Chemistry offers technical assistance and guidance in selecting the appropriate isotope-labeled compounds for your research.

Product Details:

ALL Chemistry has a large inventory of stable isotope-labeled compounds, the number of products is more than 3,500, and the specific product information is classified as follows:

Please contact us for further information, including pricing, samples, and technical specifications. We look forward to providing our isotope-labeled compound products. In addition, ALL Chemistry can provide synthesis and fine chemicals service if the existing products can't meet your needs, we expertise in synthesis of a broad array of customized molecules, and we offer lab scale custom synthesis, biosynthesis, bioconjugation and analytical services.

Custom Chemical Synthesis is the process where a molecule is made exclusively for a particular client according to specifications at their scale. It is one of the options available for pharmaceutical companies requiring active pharmaceutical ingredients (APIs), intermediates, fine chemicals, reference standards, impurities or metabolites needed to launch their research and development projects. We provide a seamless one stop process development service, effectively speeding up the process of new drug development and reducing overall costs. Available documents for custom synthesis projects: synthesis report, high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance analyses (NMR), etc.

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